Percharde Lab

Publications

[2024]

CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death. BIORXIV
Paul Chammas, Sheila Q Xie, Lessly P Sepulveda-Rincon, Bryony J Leeke, Marian H Dore, Dirk Dormann, Ryan T Wagner, Michael T McManus, Mohammad M Karimi, George Young, Michelle Percharde (2024)
https://www.biorxiv.org/content/10.1101/2024.11.25.625195v1

The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity. BIORXIV
Roshni A. de Souza, David Barneda, Donja Karimlou, Nick G.P. Bovee, Yuhan Zheng, Eveline J.E.M. Kahlman, Clara Lopes Novo, James K. Ellis, Bryony J. Leeke, Megha Prakash Bangalore, Zijing Liu, Bebiana C. Sousa, Andrea F. Lopez Clavijo, Joop H. Jansen, Mauricio Barahona, Michelle Percharde, Hector C. Keun, Mark Christian, Hendrik Marks, and Véronique Azuara* (2024)
https://www.biorxiv.org/content/10.1101/2024.09.22.613751v1

[2022]

Nucleolar-based Dux repression is essential for embryonic 2-cell stage exit. GENES & DEVELOPMENT
Xie SX, Leeke BJ, Whildling C, Wagner RT, Garcia-Llagostera F, Chammas P, Cheung NT-F, Dormann D, McManus MT, Percharde M* (2022)
https://doi.org/10.1101/gad.349172.121

[2021]

Nucleolar-based Dux repression is essential for 2-cell stage exit (preprint). BIORXIV
Xie SX, Leeke BJ, Whildling C, Wagner RT, Garcia-Llagostera F, Chammas P, Cheung NT-F, Dormann D, McManus MT, Percharde M* (2021)
https://www.biorxiv.org/content/10.1101/2021.11.11.468235v1


Depletion of nuclear LINE1 RNA in mouse ESCs and embryos. STAR PROTOCOLS
Percharde M*, Lin CJ, Ramalho-Santos M (2021)
*Lead Contact
https://doi.org/10.1016/j.xpro.2021.100726


Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome. CELL RESEARCH
Lu JY, Chang L, Li T, Wang T, Yin Y, Zhan G, Han X, Zhang K, Tao Y, Percharde M, Wang L, Peng Q, Yan P, Zhang H, Bi X, Shao W, Hong Y, Wu Z, Ma R, Wang P, Li W, Zhang J, Chang Z, Hou Y, Zhu B, Ramalho-Santos M, Li P, Xie W, Na J, Sun Y, Shen X (2021)
https://doi.org/10.1038/s41422-020-00466-6
Preprint here

[2020]

Delineating the early transcriptional specification of the mammalian trachea and esophagus. ELIFE
Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO (2020)
https://doi.org/10.7554/eLife.55526


Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation. CELL REPORTS
Lu JY, Shao W, Chang L, Yin Y, Li T, Zhang H, Hong Y, Percharde M, Guo L, Wu Z, Liu L, Liu W, Yan P, Ramalho-Santos M, Sun Y, and Shen X (2020)
https://doi.org/10.1016/j.celrep.2020.02.048


What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation. BIOESSAYS
Percharde M*, Sultana S, & Ramalho-Santos M* (2020)
*co-corresponding
https://doi.org/10.1002/bies.201900232

[2019]

L1 and B1 repeats blueprint the spatial organization of chromatin (preprint). BIORXIV
J. Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Ke Zhang, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xue Han, Xianju Bi, Wen Shao, Yantao Hong, Zhongyang Wu, Peizhe Wang, Wenzhi Li, Jing Zhang, Zai Chang, Yingping Hou, Pilong Li, Miguel Ramalho-Santos, Jie Na, Wei Xie, Yujie Sun, and Xiaohua Shen
https://doi.org/10.1101/802173


Maternal Vitamin C regulates reprogramming of DNA methylation and germline development. NATURE
DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M (2019)
https://doi.org/10.1038/s41586-019-1536-1

[2018]

A LINE1-Nucleolin partnership regulates early development and ESC identity. CELL
Percharde M, Lin CJ, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X and Ramalho-Santos M (2018)
https://doi.org/10.1016/j.cell.2018.05.043


The transcriptionally permissive chromatin state of ES cells is acutely tuned to translational output. CELL STEM CELL
Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL and Ramalho-Santos M (2018)
https://doi.org/10.1016/j.stem.2018.02.004

[2017]

Global hypertranscription in the mouse embryonic germline. CELL REPORTS
Percharde M, Wong P and Ramalho-Santos M (2017)
https://doi.org/10.1016/j.celrep.2017.05.036


Hypertranscription in development, stem cells and regeneration. DEVELOPMENTAL CELL
Percharde M, Bulut-Karslioglu A and Ramalho-Santos M (2017)
https://doi.org/10.1016/j.devcel.2016.11.010

[2016]

YAP induces human naïve pluripotency. CELL REPORTS
Qin H, Hejna M, Liu Y, Percharde M, Wossidlo M, Blouin L, Durruthy-Durruthy J, Wong P, Qi Z, Yu J, Qi LS, Sebastiano V, Song JS, Ramalho-Santos M (2016)
https://dx.doi.org/10.1016/j.celrep.2016.02.036

[2009-2013]

Essential roles for the nuclear receptor coactivator Ncoa3 in pluripotency. CELL CYCLE
Percharde M, Azuara V (2013)
https://dx.doi.org/10.4161/cc.23377


Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. GENES & DEVELOPMENT
Percharde M, Lavial F, Ng JH, Kumar V, Tomaz RA, Martin N, Yeo JC, Gil J, Prabhakar S, Ng HH, Parker MG and Azuara V (2012)
https://dx.doi.org/10.1101/gad.195545.112


The context and potential of epigenetics in oncology. BRITISH JOURNAL OF CANCER
Lopez M, Percharde M, Coley HM, Webb A and Crook T (2009), 100: 571-578
https://dx.doi.org/10.1038/sj.bjc.6604930